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Title | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. |
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Journal, issue, pages | Sci Transl Med, Vol. 14, Page eabq2096-eabq2096, Year 2022 |
Publish date | Jul 31, 2020 (structure data deposition date) |
Authors | Singh, S. / Abu-Zaid, A. / Jin, H. / Fang, J. / Wu, Q. / Wang, T. / Feng, H. / Quarni, W. / Shao, Y. / Maxham, L. ...Singh, S. / Abu-Zaid, A. / Jin, H. / Fang, J. / Wu, Q. / Wang, T. / Feng, H. / Quarni, W. / Shao, Y. / Maxham, L. / Abdolvahabi, A. / Yun, M.K. / Vaithiyalingam, S. / Tan, H. / Bowling, J. / Honnell, V. / Young, B. / Guo, Y. / Bajpai, R. / Pruett-Miller, S.M. / Grosveld, G.C. / Hatley, M. / Xu, B. / Fan, Y. / Wu, G. / Chen, E.Y. / Chen, T. / Lewis, P.W. / Rankovic, Z. / Li, Y. / Murphy, A.J. / Easton, J. / Peng, J. / Chen, X. / Wang, R. / White, S.W. / Davidoff, A.M. / Yang, J. |
External links | Sci Transl Med / PubMed:35857643 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-7jm5: |
Chemicals | ChemComp-NI: ChemComp-9DJ: ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor / KDM4 / KDM4B / PROTEIN-INHIBITOR COMPLEX / DEMETHYLASE / EPIGENETICS / OXIDOREDUCTASE-INHIBITOR COMPLEX / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex |