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-Structure paper
Title | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 7186-7210, Year 2020 |
Publish date | May 16, 2019 (structure data deposition date) |
Authors | Li, Y. / Zhao, J. / Gutgesell, L.M. / Shen, Z. / Ratia, K. / Dye, K. / Dubrovskyi, O. / Zhao, H. / Huang, F. / Tonetti, D.A. ...Li, Y. / Zhao, J. / Gutgesell, L.M. / Shen, Z. / Ratia, K. / Dye, K. / Dubrovskyi, O. / Zhao, H. / Huang, F. / Tonetti, D.A. / Thatcher, G.R.J. / Xiong, R. |
External links | J. Med. Chem. / PubMed:32453591 |
Methods | X-ray diffraction |
Resolution | 1.16 - 2.49 Å |
Structure data | PDB-6p05: PDB-7jkw: PDB-7jky: PDB-7jkz: |
Chemicals | ChemComp-GOL: ChemComp-YF2: ChemComp-HOH: ChemComp-VCV: ChemComp-YF6: ChemComp-NA: ChemComp-EDO: |
Source |
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Keywords | TRANSCRIPTION / inhibitor / brd4 / bromodomain / BRD4-BD1 Inhibitor / Selective BRD4-BD1 inhibitor |