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-Structure paper
Title | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 37, Page 116093-, Year 2021 |
Publish date | Jul 18, 2020 (structure data deposition date) |
![]() | Wallace-Povirk, A. / Tong, N. / Wong-Roushar, J. / O'Connor, C. / Zhou, X. / Hou, Z. / Bao, X. / Garcia, G.E. / Li, J. / Kim, S. ...Wallace-Povirk, A. / Tong, N. / Wong-Roushar, J. / O'Connor, C. / Zhou, X. / Hou, Z. / Bao, X. / Garcia, G.E. / Li, J. / Kim, S. / Dann, C.E. / Matherly, L.H. / Gangjee, A. |
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Methods | X-ray diffraction |
Resolution | 1.984 - 2.455 Å |
Structure data | ![]() PDB-7jg0: ![]() PDB-7jg3: ![]() PDB-7jg4: |
Chemicals | ![]() ChemComp-GAR: ![]() ChemComp-V97: ![]() ChemComp-HOH: ![]() ChemComp-V9A: ![]() ChemComp-NA: ![]() ChemComp-V9V: |
Source |
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![]() | LIGASE/LIGASE INHIBITOR / GARFTase / formyltransferase / transformylase / enzyme protein inhibitor / metabolism / alpha beta protein / Rossman fold / LIGASE / LIGASE-LIGASE INHIBITOR complex |