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-Structure paper
Title | The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 228, Page 113979-113979, Year 2022 |
Publish date | Jun 16, 2021 (structure data deposition date) |
Authors | Li, Y. / Ouyang, Y. / Wu, H. / Wang, P. / Huang, Y. / Li, X. / Chen, H. / Sun, Y. / Hu, X. / Wang, X. ...Li, Y. / Ouyang, Y. / Wu, H. / Wang, P. / Huang, Y. / Li, X. / Chen, H. / Sun, Y. / Hu, X. / Wang, X. / Li, G. / Lu, Y. / Li, C. / Lu, X. / Pang, J. / Nie, T. / Sang, X. / Dong, L. / Dong, W. / Jiang, J. / Paterson, I.C. / Yang, X. / Hong, W. / Wang, H. / You, X. |
External links | Eur. J. Med. Chem. / PubMed:34802838 |
Methods | X-ray diffraction |
Resolution | 2.81 Å |
Structure data | PDB-7f3b: |
Chemicals | ChemComp-D4C: ChemComp-GOL: |
Source |
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Keywords | ANTIBIOTIC / folate pathway / dihydrofolate reductase / catalyze the reduction of dihydrofolate to tetrahydrofolate |