+Search query
-Structure paper
Title | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. |
---|---|
Journal, issue, pages | J Enzyme Inhib Med Chem, Vol. 36, Page 903-913, Year 2021 |
Publish date | May 10, 2020 (structure data deposition date) |
Authors | Li, J. / Zou, W. / Yu, K. / Liu, B. / Liang, W. / Wang, L. / Lu, Y. / Jiang, Z. / Wang, A. / Zhu, J. |
External links | J Enzyme Inhib Med Chem / PubMed:33820450 |
Methods | X-ray diffraction |
Resolution | 1.3 - 1.73 Å |
Structure data | PDB-7c2z: PDB-7c6p: |
Chemicals | ChemComp-SQH: ChemComp-FMT: ChemComp-HOH: |
Source |
|
Keywords | GENE REGULATION / BRD4 / BD1 / 3' / 4' / 7 / 8- tetrahydroxyflavonoid / Acute myeloid leukemia / c-MYC / BD2 |