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-Structure paper
Title | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 14626-14646, Year 2020 |
Publish date | Jan 29, 2010 (structure data deposition date) |
Authors | Picado, A. / Chaikuad, A. / Wells, C.I. / Shrestha, S. / Zuercher, W.J. / Pickett, J.E. / Kwarcinski, F.E. / Sinha, P. / de Silva, C.S. / Zutshi, R. ...Picado, A. / Chaikuad, A. / Wells, C.I. / Shrestha, S. / Zuercher, W.J. / Pickett, J.E. / Kwarcinski, F.E. / Sinha, P. / de Silva, C.S. / Zutshi, R. / Liu, S. / Kannan, N. / Knapp, S. / Drewry, D.H. / Willson, T.M. |
External links | J. Med. Chem. / PubMed:33215924 |
Methods | X-ray diffraction |
Resolution | 1.75 - 2.29 Å |
Structure data | PDB-3lm5: PDB-6y6f: PDB-6y6h: PDB-6zjf: PDB-7akg: |
Chemicals | ChemComp-QUE: ChemComp-HOH: ChemComp-OD2: ChemComp-EDO: ChemComp-OBW: ChemComp-QM2: ChemComp-38O: |
Source |
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Keywords | TRANSFERASE / STK17B / serine/threonine kinase 17B / DRAK2 / DAP kinase related apoptosis-inducing protein kinase 2 / death-associated protein kinase-related 2 / Structural Genomics / Structural Genomics Consortium / SGC / Apoptosis / ATP-binding / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Serine/threonine-protein kinase / kinase inhibitor / PKIS / chemical probe / inhibitor |