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-Structure paper
Title | Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. |
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Journal, issue, pages | Bioorg. Chem., Vol. 102, Page 104003-104003, Year 2020 |
Publish date | Feb 24, 2020 (structure data deposition date) |
Authors | Chetter, B.A. / Kyriakis, E. / Barr, D. / Karra, A.G. / Katsidou, E. / Koulas, S.M. / Skamnaki, V.T. / Snape, T.J. / Psarra, A.G. / Leonidas, D.D. / Hayes, J.M. |
External links | Bioorg. Chem. / PubMed:32771768 |
Methods | X-ray diffraction |
Resolution | 2.33 - 2.4 Å |
Structure data | PDB-6y55: PDB-6y5c: PDB-6y5o: |
Chemicals | ChemComp-O9Q: ChemComp-HOH: ChemComp-O9T: ChemComp-O9Z: |
Source |
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Keywords | TRANSFERASE / glycogen metabolism |