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-Structure paper
Title | Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3character and an exquisite selectivity profile. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127405-127405, Year 2020 |
Publish date | Jun 19, 2020 (structure data deposition date) |
Authors | Bigi-Botterill, S.V. / Ivetac, A. / Bradshaw, E.L. / Cole, D. / Dougan, D.R. / Ermolieff, J. / Halkowycz, P. / Johnson, B. / McBride, C. / Pickens, J. ...Bigi-Botterill, S.V. / Ivetac, A. / Bradshaw, E.L. / Cole, D. / Dougan, D.R. / Ermolieff, J. / Halkowycz, P. / Johnson, B. / McBride, C. / Pickens, J. / Sabat, M. / Swann, S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:32738982 |
Methods | X-ray diffraction |
Resolution | 2.65 Å |
Structure data | PDB-6xih: |
Chemicals | ChemComp-V3S: ChemComp-HOH: |
Source |
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Keywords | METAL BINDING PROTEIN / TRANSFERASE / METAL-BINDING / APOPTOSIS / Serine/threonine kinase |