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-Structure paper
Title | Discovery of hydroxy pyrimidine Factor IXa inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127279-127279, Year 2020 |
Publish date | May 26, 2020 (structure data deposition date) |
Authors | Jayne, C.L. / Andreani, T. / Chan, T.Y. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. ...Jayne, C.L. / Andreani, T. / Chan, T.Y. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. / Hawes, B. / Hruza, A. / Ingram, R. / Keertikar, K.M. / Neelamkavil, S. / Reichert, P. / Xia, Y. / Chackalamannil, S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:32527459 |
Methods | X-ray diffraction |
Resolution | 1.997 - 2.513 Å |
Structure data | PDB-6x5j: PDB-6x5l: PDB-6x5p: |
Chemicals | ChemComp-GOL: ChemComp-6NH: ChemComp-NA: ChemComp-CIT: ChemComp-HOH: ChemComp-UQG: ChemComp-UQD: |
Source |
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Keywords | BLOOD CLOTTING / SERINE PROTEASE / ZYMOGEN / HYDROLASE / GLYCOPROTEIN / HYDROXYLATION / PHOSPHOPROTEIN / SULFATION / HEMOSTASIS / HEMOPHILIA / XASE-LIKE VARIANT / COMMUNICATION CHANNEL / GAMMA-CARBOXYGLUTAMIC ACID / EGF-LIKE DOMAIN / DISEASE MUTATION |