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-Structure paper
Title | The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127240-127240, Year 2020 |
Publish date | Apr 23, 2020 (structure data deposition date) |
Authors | Frohn, M. / Liu, L. / Siegmund, A.C. / Qian, W. / Amegadzie, A. / Chen, N. / Tan, H. / Hickman, D. / Wood, S. / Wen, P.H. ...Frohn, M. / Liu, L. / Siegmund, A.C. / Qian, W. / Amegadzie, A. / Chen, N. / Tan, H. / Hickman, D. / Wood, S. / Wen, P.H. / Bartberger, M.D. / Whittington, D.A. / Allen, J.R. / Bourbeau, M.P. |
External links | Bioorg. Med. Chem. Lett. / PubMed:32527542 |
Methods | X-ray diffraction |
Resolution | 1.86 Å |
Structure data | PDB-6wny: |
Chemicals | ChemComp-U64: ChemComp-IOD: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE Inhibitor / aspartic protease / amyloid precursor protein / APP / Alzheimer's disease / inhibitor / HYDROLASE / HYDROLASE-HYDROLASE Inhibitor complex |