+Search query
-Structure paper
Title | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 63, Page 5585-5623, Year 2020 |
Publish date | Jan 14, 2020 (structure data deposition date) |
Authors | Sheppard, G.S. / Wang, L. / Fidanze, S.D. / Hasvold, L.A. / Liu, D. / Pratt, J.K. / Park, C.H. / Longenecker, K. / Qiu, W. / Torrent, M. ...Sheppard, G.S. / Wang, L. / Fidanze, S.D. / Hasvold, L.A. / Liu, D. / Pratt, J.K. / Park, C.H. / Longenecker, K. / Qiu, W. / Torrent, M. / Kovar, P.J. / Bui, M. / Faivre, E. / Huang, X. / Lin, X. / Wilcox, D. / Zhang, L. / Shen, Y. / Albert, D.H. / Magoc, T.J. / Rajaraman, G. / Kati, W.M. / McDaniel, K.F. |
External links | J. Med. Chem. / PubMed:32324999 |
Methods | X-ray diffraction |
Resolution | 1.904 - 2.429 Å |
Structure data | PDB-6viw: PDB-6vix: PDB-6viy: PDB-6viz: |
Chemicals | ChemComp-QYV: ChemComp-HOH: ChemComp-QYY: |
Source |
|
Keywords | SIGNALING PROTEIN / bromodomain |