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-Structure paper
Title | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 7491-7507, Year 2020 |
Publish date | Nov 20, 2019 (structure data deposition date) |
Authors | Hecker, S.J. / Reddy, K.R. / Lomovskaya, O. / Griffith, D.C. / Rubio-Aparicio, D. / Nelson, K. / Tsivkovski, R. / Sun, D. / Sabet, M. / Tarazi, Z. ...Hecker, S.J. / Reddy, K.R. / Lomovskaya, O. / Griffith, D.C. / Rubio-Aparicio, D. / Nelson, K. / Tsivkovski, R. / Sun, D. / Sabet, M. / Tarazi, Z. / Parkinson, J. / Totrov, M. / Boyer, S.H. / Glinka, T.W. / Pemberton, O.A. / Chen, Y. / Dudley, M.N. |
External links | J. Med. Chem. / PubMed:32150407 |
Methods | X-ray diffraction |
Resolution | 1.05 - 1.8 Å |
Structure data | PDB-6v1j: PDB-6v1m: PDB-6v1o: PDB-6v1p: |
Chemicals | ChemComp-RM9: ChemComp-QNA: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: ChemComp-ZN: ChemComp-MG: ChemComp-CL: ChemComp-ACT: |
Source |
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Keywords | HYDROLASE/HYDROLASE Inhibitor / carbapenemase / boronate / inhibitor / beta-lactamase / HYDROLASE / HYDROLASE-HYDROLASE Inhibitor complex |