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TitleDirect control of CAR T cells through small molecule-regulated antibodies.
Journal, issue, pagesNat Commun, Vol. 12, Page 710-710, Year 2021
Publish dateOct 31, 2019 (structure data deposition date)
AuthorsPark, S. / Pascua, E. / Lindquist, K.C. / Kimberlin, C. / Deng, X. / Mak, Y.S.L. / Melton, Z. / Johnson, T.O. / Lin, R. / Boldajipour, B. ...Park, S. / Pascua, E. / Lindquist, K.C. / Kimberlin, C. / Deng, X. / Mak, Y.S.L. / Melton, Z. / Johnson, T.O. / Lin, R. / Boldajipour, B. / Abraham, R.T. / Pons, J. / Sasu, B.J. / Van Blarcom, T.J. / Chaparro-Riggers, J.
External linksNat Commun / PubMed:33514714
MethodsX-ray diffraction
Resolution2 - 2.2000186 Å
Structure data

PDB-6uup:
Structure of anti-hCD33 conditional scFv
Method: X-RAY DIFFRACTION / Resolution: 2.2000186 Å

PDB-6uy3:
Structure of anti-hCD33 conditional scFv with methotrexate
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-K:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MTX:
METHOTREXATE / chemotherapy*YM

Source
  • camelidae mixed library (mammal)
KeywordsANTITUMOR PROTEIN / Conditional CAR / MTX / CD33 / conditional antibody

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