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Title | Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 1298-1312, Year 2020 |
Publish date | Oct 6, 2019 (structure data deposition date) |
Authors | Kang, D. / Ruiz, F.X. / Feng, D. / Pilch, A. / Zhao, T. / Wei, F. / Wang, Z. / Sun, Y. / Fang, Z. / De Clercq, E. ...Kang, D. / Ruiz, F.X. / Feng, D. / Pilch, A. / Zhao, T. / Wei, F. / Wang, Z. / Sun, Y. / Fang, Z. / De Clercq, E. / Pannecouque, C. / Arnold, E. / Liu, X. / Zhan, P. |
External links | J. Med. Chem. / PubMed:31935327 |
Methods | X-ray diffraction |
Resolution | 2.23 Å |
Structure data | PDB-6ul5: |
Chemicals | ChemComp-QAG: ChemComp-SO4: ChemComp-EDO: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Human immunodeficiency virus 1 / non nucleotide-reverse transcriptase inhibitor |