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-Structure paper
Title | A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. |
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Journal, issue, pages | Cell Chem Biol, Vol. 28, Page 835-, Year 2021 |
Publish date | Jan 8, 2020 (structure data deposition date) |
Authors | Scott, D.E. / Francis-Newton, N.J. / Marsh, M.E. / Coyne, A.G. / Fischer, G. / Moschetti, T. / Bayly, A.R. / Sharpe, T.D. / Haas, K.T. / Barber, L. ...Scott, D.E. / Francis-Newton, N.J. / Marsh, M.E. / Coyne, A.G. / Fischer, G. / Moschetti, T. / Bayly, A.R. / Sharpe, T.D. / Haas, K.T. / Barber, L. / Valenzano, C.R. / Srinivasan, R. / Huggins, D.J. / Lee, M. / Emery, A. / Hardwick, B. / Ehebauer, M. / Dagostin, C. / Esposito, A. / Pellegrini, L. / Perrior, T. / McKenzie, G. / Blundell, T.L. / Hyvonen, M. / Skidmore, J. / Venkitaraman, A.R. / Abell, C. |
External links | Cell Chem Biol / PubMed:33662256 |
Methods | X-ray diffraction |
Resolution | 1.352 - 2.31 Å |
Structure data | PDB-6tv3: PDB-6tw3: PDB-6tw4: PDB-6tw9: PDB-6xtw: |
Chemicals | ChemComp-NYE: ChemComp-PO4: ChemComp-GOL: ChemComp-HOH: ChemComp-O0E: ChemComp-NZW: ChemComp-CA: ChemComp-O08: ChemComp-SO4: |
Source |
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Keywords | DNA BINDING PROTEIN / RAD51 / RECOMBINASE / DNA REPAIR |