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-Structure paper
Title | Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. |
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Journal, issue, pages | Chemmedchem, Vol. 15, Page 571-584, Year 2020 |
Publish date | Dec 2, 2019 (structure data deposition date) |
Authors | Kalinin, D.V. / Jana, S.K. / Pfafenrot, M. / Chakrabarti, A. / Melesina, J. / Shaik, T.B. / Lancelot, J. / Pierce, R.J. / Sippl, W. / Romier, C. ...Kalinin, D.V. / Jana, S.K. / Pfafenrot, M. / Chakrabarti, A. / Melesina, J. / Shaik, T.B. / Lancelot, J. / Pierce, R.J. / Sippl, W. / Romier, C. / Jung, M. / Holl, R. |
External links | Chemmedchem / PubMed:31816172 |
Methods | X-ray diffraction |
Resolution | 1.61 Å |
Structure data | PDB-6tld: |
Chemicals | ChemComp-ZN: ChemComp-K: ChemComp-NK5: ChemComp-DMF: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Epigenetics / Histone deacetylase / HDAC8 / Selective inhibitor / Pathogen |