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-Structure paper
Title | Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 244, Page 114878-114878, Year 2022 |
Publish date | Oct 25, 2019 (structure data deposition date) |
Authors | de Lucio, H. / Revuelto, A. / Carriles, A.A. / de Castro, S. / Garcia-Gonzalez, S. / Garcia-Soriano, J.C. / Alcon-Calderon, M. / Sanchez-Murcia, P.A. / Hermoso, J.A. / Gago, F. ...de Lucio, H. / Revuelto, A. / Carriles, A.A. / de Castro, S. / Garcia-Gonzalez, S. / Garcia-Soriano, J.C. / Alcon-Calderon, M. / Sanchez-Murcia, P.A. / Hermoso, J.A. / Gago, F. / Camarasa, M.J. / Jimenez-Ruiz, A. / Velazquez, S. |
External links | Eur. J. Med. Chem. / PubMed:36332553 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3 Å |
Structure data | PDB-6t95: PDB-6t98: |
Chemicals | ChemComp-FAD: ChemComp-DMS: ChemComp-GOL: ChemComp-SO4: ChemComp-MWT: ChemComp-HOH: ChemComp-MWZ: |
Source |
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Keywords | FLAVOPROTEIN / Inhibitor / Complex / Oxidoreductase / Leishmania / Drug |