Title Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Journal, issue, pages Acs Chem. Biol. , Vol. 15, Page 618-625, Year 2020Publish date Oct 1, 2019 (structure data deposition date) AuthorsBedi, R.K. / Huang, D. / Wiedmer, L. / Li, Y. / Dolbois, A. / Wojdyla, J.A. / Sharpe, M.E. / Caflisch, A. / Sledz, P. External links Acs Chem. Biol. / PubMed:32101404Methods X-ray diffraction Resolution 1.1 - 2.4 Å Structure data PDB-6syz : Structure viewer Crystal structure of YTHDC1 with fragment 1 (DHU_DC1_141) Method : X-RAY DIFFRACTION / Resolution : 2.28 Å
PDB-6sz1 : Structure viewer Crystal structure of YTHDC1 with fragment 2 (DHU_DC1_140) Method : X-RAY DIFFRACTION / Resolution : 1.75 Å
PDB-6sz2 : Structure viewer Crystal structure of YTHDC1 with fragment 3 (DHU_DC1_149) Method : X-RAY DIFFRACTION / Resolution : 1.52 Å
PDB-6sz3 : Structure viewer Crystal structure of YTHDC1 with fragment 4 (DHU_DC1_158) Method : X-RAY DIFFRACTION / Resolution : 1.28 Å
PDB-6sz7 : Structure viewer Crystal structure of YTHDC1 with fragment 5 (DHU_DC1_066) Method : X-RAY DIFFRACTION / Resolution : 2.31 Å
PDB-6sz8 : Structure viewer Crystal structure of YTHDC1 with fragment 6 (DHU_DC1_034) Method : X-RAY DIFFRACTION / Resolution : 1.47 Å
PDB-6szl : Structure viewer Crystal structure of YTHDC1 with fragment 7 (DHU_DC1_021) Method : X-RAY DIFFRACTION / Resolution : 1.45 Å
PDB-6szn : Structure viewer Crystal structure of YTHDC1 with fragment 8 (DHU_DC1_006) Method : X-RAY DIFFRACTION / Resolution : 1.47 Å
PDB-6szr : Structure viewer Crystal structure of YTHDC1 with fragment 9 (DHU_DC1_107) Method : X-RAY DIFFRACTION / Resolution : 1.64 Å
PDB-6szt : Structure viewer Crystal structure of YTHDC1 with fragment 10 (DHU_DC1_076) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6szx : Structure viewer Crystal structure of YTHDC1 with fragment 11 (DHU_DC1_128) Method : X-RAY DIFFRACTION / Resolution : 1.17 Å
PDB-6szy : Structure viewer Crystal structure of YTHDC1 with fragment 12 (DHU_DC1_150) Method : X-RAY DIFFRACTION / Resolution : 1.79 Å
PDB-6t01 : Structure viewer Crystal structure of YTHDC1 with fragment 13 (DHU_DC1_153) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6t02 : Structure viewer Crystal structure of YTHDC1 with fragment 15 (DHU_DC1_169) Method : X-RAY DIFFRACTION / Resolution : 1.1 Å
PDB-6t03 : Structure viewer Crystal structure of YTHDC1 with fragment 16 (DHU_DC1_017) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6t04 : Structure viewer Crystal structure of YTHDC1 with fragment 17 (DHU_DC1_042) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6t05 : Structure viewer Crystal structure of YTHDC1 with fragment 18 (DHU_DC1_048) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6t06 : Structure viewer Crystal structure of YTHDC1 with fragment 19 (DHU_DC1_045) Method : X-RAY DIFFRACTION / Resolution : 2.4 Å
PDB-6t07 : Structure viewer Crystal structure of YTHDC1 with fragment 20 (DHU_DC1_134) Method : X-RAY DIFFRACTION / Resolution : 1.5 Å
PDB-6t08 : Structure viewer Crystal structure of YTHDC1 with fragment 21 (DHU_DC1_131) Method : X-RAY DIFFRACTION / Resolution : 1.41 Å
PDB-6t09 : Structure viewer Crystal structure of YTHDC1 with fragment 24 (PSI_DC1_003) Method : X-RAY DIFFRACTION / Resolution : 1.75 Å
PDB-6t0a : Structure viewer Crystal structure of YTHDC1 with fragment 25 (PSI_DC1_005) Method : X-RAY DIFFRACTION / Resolution : 2.02 Å
PDB-6t0c : Structure viewer Crystal structure of YTHDC1 with fragment 26 (DHU_DC1_198) Method : X-RAY DIFFRACTION / Resolution : 2.03 Å
PDB-6t0d : Structure viewer Crystal structure of YTHDC1 with fragment 27 (DHU_DC1_256) Method : X-RAY DIFFRACTION / Resolution : 1.43 Å
PDB-6t0o : Structure viewer Crystal structure of YTHDC1 with fragment 14 (ACA_DC1_004) Method : X-RAY DIFFRACTION / Resolution : 1.71 Å
PDB-6t0x : Structure viewer Crystal structure of YTHDC1 with fragment 22 (ACA_DC1_001) Method : X-RAY DIFFRACTION / Resolution : 1.36 Å
PDB-6t0z : Structure viewer Crystal structure of YTHDC1 with fragment 23 (ACA_DC1_005) Method : X-RAY DIFFRACTION / Resolution : 1.43 Å
PDB-6t10 : Structure viewer Crystal structure of YTHDC1 with fragment 28 (DHU_DC1_176) Method : X-RAY DIFFRACTION / Resolution : 1.48 Å
PDB-6t11 : Structure viewer Crystal structure of YTHDC1 with fragment 29 (DHU_DC1_218) Method : X-RAY DIFFRACTION / Resolution : 1.49 Å
PDB-6t12 : Structure viewer Crystal structure of YTHDC1 with fragment 30 (DHU_DC1_220) Method : X-RAY DIFFRACTION / Resolution : 1.46 Å
Chemicals ChemComp-M1E : Structure viewer ~{N}-methylthieno[3,2-d]pyrimidin-4-amine
ChemComp-M0Q : Structure viewer ~{N}-methyl-1,6-naphthyridin-4-amine
ChemComp-M1H : Structure viewer ~{N}-methyl-5,6,7,8-tetrahydroquinolin-4-amine
ChemComp-M1Q : Structure viewer 5,6,7,8-tetrahydro-4~{a}~{H}-quinazoline-2,4-dione
ChemComp-M1Z : Structure viewer 6-pyrrolidin-1-yl-5~{H}-pyrimidine-2,4-dione
ChemComp-M3E : Structure viewer 6-phenyl-1~{H}-pyrimidine-2,4-dione
ChemComp-M3Z : Structure viewer 6-[[methyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M4Q : Structure viewer 6-[[methyl(thiophen-3-ylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M4K : Structure viewer 6-[[cyclopropyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione
ChemComp-M5N : Structure viewer 4-propan-2-yl-5,6,7,8-tetrahydro-4~{a}~{H}-quinazolin-2-one
ChemComp-M4B : Structure viewer 6-methyl-5-nitro-4-phenyl-1~{H}-pyrimidin-2-one
ChemComp-M5E : Structure viewer (~{S})-phenyl-[(2~{S})-pyrrolidin-2-yl]methanol
ChemComp-M3H : Structure viewer 2-phenyl-4,5-dihydro-1~{H}-imidazole
ChemComp-M5H : Structure viewer 3-imidazolidin-2-yl-2~{H}-indazole
ChemComp-M45 : Structure viewer ~{N}-[(2~{S})-pyrrolidin-2-yl]-1~{H}-1,2,4-triazol-5-amine
ChemComp-M5B : Structure viewer ~{N}-(1~{H}-imidazol-2-yl)thiophene-2-sulfonamide
ChemComp-M58 : Structure viewer (~{R})-azanyl(pyridin-3-yl)methanethiol
ChemComp-M4E : Structure viewer ~{N}-methyl-2~{H}-indazole-3-carboxamide
ChemComp-M4N : Structure viewer ~{N}-methyl-3-phenyl-1~{H}-pyrazole-5-carboxamide
ChemComp-M6N : Structure viewer 2-methyl-3~{H}-pyrido[3,4-d]pyrimidin-4-one
ChemComp-M6W : Structure viewer (3~{S})-~{N}-methylpyrrolidine-3-carboxamide
ChemComp-M75 : Structure viewer ~{N}-cyclopropyl-1~{H}-imidazole-4-sulfonamide
ChemComp-M6Z : Structure viewer 5-iodanyl-~{N}-methyl-1~{H}-indazole-3-carboxamide
ChemComp-O2A : Structure viewer N-methyl-1H-indole-7-carboxamide
ChemComp-M78 : Structure viewer ~{N},2,3-trimethyl-1~{H}-indole-5-carboxamide
Source homo sapiens (human) Keywords RNA BINDING PROTEIN / Fragment / Complex / YTHDC1 / Epitranscriptomic