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Structure paper

TitleStructural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
Journal, issue, pagesBiochem. J., Vol. 476, Page 1553-1570, Year 2019
Publish dateFeb 20, 2019 (structure data deposition date)
AuthorsSturrock, E.D. / Lubbe, L. / Cozier, G.E. / Schwager, S.L.U. / Arowolo, A.T. / Arendse, L.B. / Belcher, E. / Acharya, K.R.
External linksBiochem. J. / PubMed:31072910
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-6qs1:
Crystal structure of human Angiotensin-1 converting enzyme N-domain in complex with BPPb
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-XPE:
3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-BO3:
BORIC ACID

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • gloydius blomhoffii (mamushi)
KeywordsHYDROLASE / Angiotensin-1 converting enzyme / ACE inhibitor / Bradykinin potentiating peptide / Vasopeptidase inhibitor

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