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-Structure paper
Title | Discovery of AM-6494: A Potent and Orally Efficacious beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 2263-2281, Year 2020 |
Publish date | Jul 31, 2019 (structure data deposition date) |
Authors | Pettus, L.H. / Bourbeau, M.P. / Bradley, J. / Bartberger, M.D. / Chen, K. / Hickman, D. / Johnson, M. / Liu, Q. / Manning, J.R. / Nanez, A. ...Pettus, L.H. / Bourbeau, M.P. / Bradley, J. / Bartberger, M.D. / Chen, K. / Hickman, D. / Johnson, M. / Liu, Q. / Manning, J.R. / Nanez, A. / Siegmund, A.C. / Wen, P.H. / Whittington, D.A. / Allen, J.R. / Wood, S. |
External links | J. Med. Chem. / PubMed:31589043 |
Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | PDB-6pz4: |
Chemicals | ChemComp-IOD: ChemComp-GOL: ChemComp-P6J: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / BACE / inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |