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Structure paper

TitleDNA polymerase beta nucleotide-stabilized template misalignment fidelity depends on local sequence context.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 529-538, Year 2020
Publish dateJun 25, 2019 (structure data deposition date)
AuthorsHoward, M.J. / Cavanaugh, N.A. / Batra, V.K. / Shock, D.D. / Beard, W.A. / Wilson, S.H.
External linksJ. Biol. Chem. / PubMed:31801827
MethodsX-ray diffraction
Resolution2.6 - 2.602 Å
Structure data

PDB-6ph5:
Binary product complex crystal structure of DNA polymerase Beta with an extra-helical template base
Method: X-RAY DIFFRACTION / Resolution: 2.602 Å

PDB-6ph6:
Ternary complex crystal structure of DNA polymerase Beta with 2nt-gap with dCTP bound downstream
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
Keywordstranscription/dna / DNA Polymerase Beta / Conformational Change / enzyme mechanism / misalignment mutagenesis / transcription-dna complex

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