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-Structure paper
Title | Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 10740-10756, Year 2019 |
Publish date | May 15, 2019 (structure data deposition date) |
Authors | Himmelbauer, M.K. / Xin, Z. / Jones, J.H. / Enyedy, I. / King, K. / Marcotte, D.J. / Murugan, P. / Santoro, J.C. / Hesson, T. / Spilker, K. ...Himmelbauer, M.K. / Xin, Z. / Jones, J.H. / Enyedy, I. / King, K. / Marcotte, D.J. / Murugan, P. / Santoro, J.C. / Hesson, T. / Spilker, K. / Johnson, J.L. / Luzzio, M.J. / Gilfillan, R. / de Turiso, F.G. |
External links | J. Med. Chem. / PubMed:31710475 |
Methods | X-ray diffraction |
Resolution | 2.603 - 2.824 Å |
Structure data | PDB-6oyt: PDB-6oyw: |
Chemicals | ChemComp-NJV: ChemComp-ACT: ChemComp-HOH: ChemComp-NKJ: ChemComp-MG: |
Source |
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Keywords | Transferase/Transferase Inhibitor / ASK1 MAP3K5 / Transferase-Transferase Inhibitor complex / TRANSFERASE |