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-Structure paper
Title | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. |
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Journal, issue, pages | Nat Commun, Vol. 10, Page 5795-5795, Year 2019 |
Publish date | Apr 23, 2019 (structure data deposition date) |
Authors | O'Connell, J. / Porter, J. / Kroeplien, B. / Norman, T. / Rapecki, S. / Davis, R. / McMillan, D. / Arakaki, T. / Burgin, A. / Fox Iii, D. ...O'Connell, J. / Porter, J. / Kroeplien, B. / Norman, T. / Rapecki, S. / Davis, R. / McMillan, D. / Arakaki, T. / Burgin, A. / Fox Iii, D. / Ceska, T. / Lecomte, F. / Maloney, A. / Vugler, A. / Carrington, B. / Cossins, B.P. / Bourne, T. / Lawson, A. |
External links | Nat Commun / PubMed:31857588 |
Methods | X-ray diffraction |
Resolution | 2.5 - 2.8 Å |
Structure data | PDB-6ooy: PDB-6ooz: PDB-6op0: |
Chemicals | ChemComp-MRD: ChemComp-A7M: ChemComp-HOH: ChemComp-CL: ChemComp-A6Y: ChemComp-A7A: |
Source |
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Keywords | CYTOKINE / Tumour necrosis factor alpha / TNF / asymmetric / protein-protein interaction inhibitor / rheumatoid arthritis |