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-Structure paper
Title | Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 9, Page 1230-1234, Year 2018 |
Publish date | Nov 13, 2018 (structure data deposition date) |
![]() | Fell, J.B. / Fischer, J.P. / Baer, B.R. / Ballard, J. / Blake, J.F. / Bouhana, K. / Brandhuber, B.J. / Briere, D.M. / Burgess, L.E. / Burkard, M.R. ...Fell, J.B. / Fischer, J.P. / Baer, B.R. / Ballard, J. / Blake, J.F. / Bouhana, K. / Brandhuber, B.J. / Briere, D.M. / Burgess, L.E. / Burkard, M.R. / Chiang, H. / Chicarelli, M.J. / Davidson, K. / Gaudino, J.J. / Hallin, J. / Hanson, L. / Hee, K. / Hicken, E.J. / Hinklin, R.J. / Marx, M.A. / Mejia, M.J. / Olson, P. / Savechenkov, P. / Sudhakar, N. / Tang, T.P. / Vigers, G.P. / Zecca, H. / Christensen, J.G. |
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Methods | X-ray diffraction |
Resolution | 1.72 - 1.8 Å |
Structure data | ![]() PDB-6n2j: ![]() PDB-6n2k: |
Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-K9M: ![]() ChemComp-HOH: ![]() ChemComp-K9J: |
Source |
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![]() | ONCOPROTEIN / KRAS proto-oncogene / GTPase |