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| Title | Design and Discovery ofN-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. |
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| Journal, issue, pages | J. Med. Chem., Vol. 63, Page 2013-2027, Year 2020 |
| Publish date | Nov 7, 2018 (structure data deposition date) |
 Authors | Ramurthy, S. / Taft, B.R. / Aversa, R.J. / Barsanti, P.A. / Burger, M.T. / Lou, Y. / Nishiguchi, G.A. / Rico, A. / Setti, L. / Smith, A. ...Ramurthy, S. / Taft, B.R. / Aversa, R.J. / Barsanti, P.A. / Burger, M.T. / Lou, Y. / Nishiguchi, G.A. / Rico, A. / Setti, L. / Smith, A. / Subramanian, S. / Tamez, V. / Tanner, H. / Wan, L. / Hu, C. / Appleton, B.A. / Mamo, M. / Tandeske, L. / Tellew, J.E. / Huang, S. / Yue, Q. / Chaudhary, A. / Tian, H. / Iyer, R. / Hassan, A.Q. / Mathews Griner, L.A. / La Bonte, L.R. / Cooke, V.G. / Van Abbema, A. / Merritt, H. / Gampa, K. / Feng, F. / Yuan, J. / Mishina, Y. / Wang, Y. / Haling, J.R. / Vaziri, S. / Hekmat-Nejad, M. / Polyakov, V. / Zang, R. / Sethuraman, V. / Amiri, P. / Singh, M. / Sellers, W.R. / Lees, E. / Shao, W. / Dillon, M.P. / Stuart, D.D. |
 External links | J. Med. Chem. / PubMed:31059256 |
| Methods | X-ray diffraction |
| Resolution | 2.04 - 2.37 Å |
| Structure data |  PDB-6n0p:  PDB-6n0q: |
| Chemicals |  ChemComp-K81:  ChemComp-HOH:  ChemComp-K7S: |
| Source |
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 Keywords | transferase/transferase inhibitor / Raf / bRaf / cRaf / CRAF kinase / Serine threonine protein / TRANSFERASE / transferase-transferase inhibitor complex |
homo sapiens (human)