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TitleCrystal structure of the mineralocorticoid receptor ligand-binding domain in complex with a potent and selective nonsteroidal blocker, esaxerenone (CS-3150).
Journal, issue, pagesFebs Lett., Vol. 594, Page 1615-1623, Year 2020
Publish dateNov 5, 2019 (structure data deposition date)
AuthorsTakahashi, M. / Ubukata, O. / Homma, T. / Asoh, Y. / Honzumi, M. / Hayashi, N. / Saito, K. / Tsuruoka, H. / Aoki, K. / Hanzawa, H.
External linksFebs Lett. / PubMed:31991486
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-6l88:
Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-E6R:
1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide / antagonist, hormone*YM

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Nuclear receptor / Hypertension / NUCLEAR PROTEIN

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