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-Structure paper
Title | Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. |
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Journal, issue, pages | Biochem. Biophys. Res. Commun., Vol. 509, Page 943-948, Year 2019 |
Publish date | Oct 15, 2018 (structure data deposition date) |
Authors | Yasutake, Y. / Hattori, S.I. / Tamura, N. / Matsuda, K. / Kohgo, S. / Maeda, K. / Mitsuya, H. |
External links | Biochem. Biophys. Res. Commun. / PubMed:30648556 |
Methods | X-ray diffraction |
Resolution | 2.435 - 2.598 Å |
Structure data | PDB-6ik9: PDB-6ika: |
Chemicals | ChemComp-DGT: ChemComp-MG: ChemComp-GOL: ChemComp-HOH: ChemComp-ET9: |
Source |
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Keywords | TRANSFERASE/DNA / HIV-1 / HBV / reverse transcriptase / drug resistance / drug sensitivity / entecavir / TRANSFERASE-DNA complex / REPLICATION / ENTECAVIR 5'-TRIPHOSPHATE |