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Title | Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 646-653, Year 2019 |
Publish date | Dec 1, 2018 (structure data deposition date) |
Authors | Boutard, N. / Bialas, A. / Sabiniarz, A. / Guzik, P. / Banaszak, K. / Biela, A. / Bien, M. / Buda, A. / Bugaj, B. / Cieluch, E. ...Boutard, N. / Bialas, A. / Sabiniarz, A. / Guzik, P. / Banaszak, K. / Biela, A. / Bien, M. / Buda, A. / Bugaj, B. / Cieluch, E. / Cierpich, A. / Dudek, L. / Eggenweiler, H.M. / Fogt, J. / Gaik, M. / Gondela, A. / Jakubiec, K. / Jurzak, M. / Kitlinska, A. / Kowalczyk, P. / Kujawa, M. / Kwiecinska, K. / Les, M. / Lindemann, R. / Maciuszek, M. / Mikulski, M. / Niedziejko, P. / Obara, A. / Pawlik, H. / Rzymski, T. / Sieprawska-Lupa, M. / Sowinska, M. / Szeremeta-Spisak, J. / Stachowicz, A. / Tomczyk, M.M. / Wiklik, K. / Wloszczak, L. / Ziemianska, S. / Zarebski, A. / Brzozka, K. / Nowak, M. / Fabritius, C.H. |
External links | Bioorg. Med. Chem. Lett. / PubMed:30626557 |
Methods | X-ray diffraction |
Resolution | 2.11 - 2.6 Å |
Structure data | PDB-6ibx: PDB-6iby: PDB-6ibz: PDB-6ic0: |
Chemicals | ChemComp-H9Z: ChemComp-POP: ChemComp-FLC: ChemComp-F6P: ChemComp-DMS: ChemComp-HOH: ChemComp-HAT: ChemComp-BME: ChemComp-PO4: ChemComp-HAW: ChemComp-HAK: |
Source |
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Keywords | TRANSFERASE / Cancer / Metabolism / Kinase / Inhibitor |