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-Structure paper
Title | Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 10922-10928, Year 2018 |
Publish date | Sep 18, 2018 (structure data deposition date) |
![]() | You, W. / Steegborn, C. |
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Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-6hoy: |
Chemicals | ![]() ChemComp-AR6: ![]() ChemComp-ZN: ![]() ChemComp-PG4: ![]() ChemComp-EDO: ![]() ChemComp-SO4: ![]() ChemComp-TSN: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Deacylase / Inhibitor / Hydroxamate / Non-competitive / Isoform-selective |