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-Structure paper
Title | Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 28, Page 3458-3462, Year 2018 |
Publish date | Sep 12, 2018 (structure data deposition date) |
Authors | Barker, M.D. / Liddle, J. / Atkinson, F.L. / Wilson, D.M. / Dickson, M.C. / Ramirez-Molina, C. / Lewis, H. / Davis, R.P. / Somers, D.O. / Neu, M. ...Barker, M.D. / Liddle, J. / Atkinson, F.L. / Wilson, D.M. / Dickson, M.C. / Ramirez-Molina, C. / Lewis, H. / Davis, R.P. / Somers, D.O. / Neu, M. / Jones, E. / Watson, R. |
External links | Bioorg. Med. Chem. Lett. / PubMed:30249354 |
Methods | X-ray diffraction |
Resolution | 1.64 - 2.1 Å |
Structure data | PDB-6hm6: PDB-6hm7: |
Chemicals | ChemComp-GDK: ChemComp-GOL: ChemComp-HOH: ChemComp-GDH: ChemComp-BR: ChemComp-DMS: |
Source |
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Keywords | TRANSFERASE / SK363 / SYK / non-receptor tyrosine kinase / spleen tyrosine kinase |