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-Structure paper
Title | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 15, Page 672-680, Year 2019 |
Publish date | Aug 9, 2018 (structure data deposition date) |
Authors | Farnaby, W. / Koegl, M. / Roy, M.J. / Whitworth, C. / Diers, E. / Trainor, N. / Zollman, D. / Steurer, S. / Karolyi-Oezguer, J. / Riedmueller, C. ...Farnaby, W. / Koegl, M. / Roy, M.J. / Whitworth, C. / Diers, E. / Trainor, N. / Zollman, D. / Steurer, S. / Karolyi-Oezguer, J. / Riedmueller, C. / Gmaschitz, T. / Wachter, J. / Dank, C. / Galant, M. / Sharps, B. / Rumpel, K. / Traxler, E. / Gerstberger, T. / Schnitzer, R. / Petermann, O. / Greb, P. / Weinstabl, H. / Bader, G. / Zoephel, A. / Weiss-Puxbaum, A. / Ehrenhofer-Wolfer, K. / Wohrle, S. / Boehmelt, G. / Rinnenthal, J. / Arnhof, H. / Wiechens, N. / Wu, M.Y. / Owen-Hughes, T. / Ettmayer, P. / Pearson, M. / McConnell, D.B. / Ciulli, A. |
External links | Nat. Chem. Biol. / PubMed:31178587 |
Methods | X-ray diffraction |
Resolution | 1.31 - 2.35 Å |
Structure data | PDB-6hax: PDB-6hay: PDB-6haz: PDB-6hr2: |
Chemicals | ChemComp-EDO: ChemComp-FWZ: ChemComp-EPE: ChemComp-HOH: ChemComp-FX8: ChemComp-FMT: ChemComp-FX5: ChemComp-ZN: ChemComp-DMS: |
Source |
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Keywords | GENE REGULATION / bromodomain / E3 Ubiquitin Protein Ligase / TRANSCRIPTION / BRG1 / SMARCA4 / PROTAC / VHL / ternary complex |