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-Structure paper
Title | Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 10, Page 1561-1567, Year 2019 |
Publish date | Jun 21, 2018 (structure data deposition date) |
Authors | Ouvry, G. / Clary, L. / Tomas, L. / Aurelly, M. / Bonnary, L. / Borde, E. / Bouix-Peter, C. / Chantalat, L. / Defoin-Platel, C. / Deret, S. ...Ouvry, G. / Clary, L. / Tomas, L. / Aurelly, M. / Bonnary, L. / Borde, E. / Bouix-Peter, C. / Chantalat, L. / Defoin-Platel, C. / Deret, S. / Forissier, M. / Harris, C.S. / Isabet, T. / Lamy, L. / Luzy, A.P. / Pascau, J. / Soulet, C. / Taddei, A. / Taquet, N. / Thoreau, E. / Varvier, E. / Vial, E. / Hennequin, L.F. |
External links | Acs Med. Chem. Lett. / PubMed:31749911 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3 Å |
Structure data | PDB-6gvf: PDB-6gvg: PDB-6gvh: PDB-6gvi: |
Chemicals | ChemComp-FE5: ChemComp-HOH: ChemComp-FCZ: ChemComp-FDH: ChemComp-FDW: |
Source |
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Keywords | TRANSFERASE / LIPID KINASE / INHIBITOR / PI3K ALPHA / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE-TRANSFERASE REGULATOR COMPLEX |