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-Structure paper
Title | Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. |
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Journal, issue, pages | ACS Chem. Biol., Vol. 13, Page 2190-2202, Year 2018 |
Publish date | Feb 2, 2018 (structure data deposition date) |
![]() | Silvestri, I. / Lyu, H. / Fata, F. / Boumis, G. / Miele, A.E. / Ardini, M. / Ippoliti, R. / Bellelli, A. / Jadhav, A. / Lea, W.A. ...Silvestri, I. / Lyu, H. / Fata, F. / Boumis, G. / Miele, A.E. / Ardini, M. / Ippoliti, R. / Bellelli, A. / Jadhav, A. / Lea, W.A. / Simeonov, A. / Cheng, Q. / Arner, E.S.J. / Thatcher, G.R.J. / Petukhov, P.A. / Williams, D.L. / Angelucci, F. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 2.501 Å |
Structure data | ![]() PDB-6fmu: ![]() PDB-6fmz: ![]() PDB-6fp4: ![]() PDB-6ftc: |
Chemicals | ![]() ChemComp-FAD: ![]() ChemComp-DVK: ![]() ChemComp-PGE: ![]() ChemComp-HOH: ![]() ChemComp-DVQ: ![]() ChemComp-E1T: ![]() ChemComp-NA: ![]() ChemComp-250: ![]() ChemComp-EPE: ![]() ChemComp-PG4: ![]() ChemComp-PEG: |
Source |
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![]() | FLAVOPROTEIN / Fragment / Allosteric pocket / Schistosomiasis / FAD/NAD linked reductase |