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Title | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 10665-10699, Year 2018 |
Publish date | May 1, 2018 (structure data deposition date) |
Authors | Casimiro-Garcia, A. / Trujillo, J.I. / Vajdos, F. / Juba, B. / Banker, M.E. / Aulabaugh, A. / Balbo, P. / Bauman, J. / Chrencik, J. / Coe, J.W. ...Casimiro-Garcia, A. / Trujillo, J.I. / Vajdos, F. / Juba, B. / Banker, M.E. / Aulabaugh, A. / Balbo, P. / Bauman, J. / Chrencik, J. / Coe, J.W. / Czerwinski, R. / Dowty, M. / Knafels, J.D. / Kwon, S. / Leung, L. / Liang, S. / Robinson, R.P. / Telliez, J.B. / Unwalla, R. / Yang, X. / Thorarensen, A. |
External links | J. Med. Chem. / PubMed:30423248 |
Methods | X-ray diffraction |
Resolution | 1.66 - 2.9 Å |
Structure data | PDB-6da4: PDB-6db3: PDB-6db4: PDB-6dud: |
Chemicals | ChemComp-G4V: ChemComp-HOH: ChemComp-G54: ChemComp-G4Y: ChemComp-HB4: ChemComp-SO4: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / kinase / covalent / TRANSFERASE-INHIBITOR complex / TRANSFERASE/TRANSFERASE inhibitor / TRANSFERASE-TRANSFERASE inhibitor complex |