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-Structure paper
Title | Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 26, Page 5443-5461, Year 2018 |
Publish date | Mar 14, 2018 (structure data deposition date) |
Authors | Beyett, T.S. / Gan, X. / Reilly, S.M. / Gomez, A.V. / Chang, L. / Tesmer, J.J.G. / Saltiel, A.R. / Showalter, H.D. |
External links | Bioorg. Med. Chem. / PubMed:30270002 |
Methods | X-ray diffraction |
Resolution | 3.19 - 3.354 Å |
Structure data | PDB-6cq0: PDB-6cq4: PDB-6cq5: |
Chemicals | ChemComp-F8M: ChemComp-F8P: ChemComp-F8S: |
Source |
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Keywords | TRANSFERASE / TBK1 / kinase / amlexanox |