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-Structure paper
Title | Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 6110-6120, Year 2018 |
Publish date | Jan 23, 2018 (structure data deposition date) |
Authors | Zhao, Y. / Zhou, B. / Bai, L. / Liu, L. / Yang, C.Y. / Meagher, J.L. / Stuckey, J.A. / McEachern, D. / Przybranowski, S. / Wang, M. ...Zhao, Y. / Zhou, B. / Bai, L. / Liu, L. / Yang, C.Y. / Meagher, J.L. / Stuckey, J.A. / McEachern, D. / Przybranowski, S. / Wang, M. / Ran, X. / Aguilar, A. / Hu, Y. / Kampf, J.W. / Li, X. / Zhao, T. / Li, S. / Wen, B. / Sun, D. / Wang, S. |
External links | J. Med. Chem. / PubMed:30015487 |
Methods | X-ray diffraction |
Resolution | 1.5 - 1.51 Å |
Structure data | PDB-6c7q: PDB-6c7r: |
Chemicals | ChemComp-EO1: ChemComp-HOH: ChemComp-EO4: |
Source |
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Keywords | transcription/transcription inhibitor / BROMODOMAIN / TRANSCRIPTION / transcription-transcription inhibitor complex |