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-Structure paper
Title | Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 4832-4850, Year 2018 |
Publish date | Dec 19, 2017 (structure data deposition date) |
Authors | Borkin, D. / Klossowski, S. / Pollock, J. / Miao, H. / Linhares, B.M. / Kempinska, K. / Jin, Z. / Purohit, T. / Wen, B. / He, M. ...Borkin, D. / Klossowski, S. / Pollock, J. / Miao, H. / Linhares, B.M. / Kempinska, K. / Jin, Z. / Purohit, T. / Wen, B. / He, M. / Sun, D. / Cierpicki, T. / Grembecka, J. |
External links | J. Med. Chem. / PubMed:29738674 |
Methods | X-ray diffraction |
Resolution | 1.82 - 1.9 Å |
Structure data | PDB-6bxy: PDB-6by8: |
Chemicals | ChemComp-EEV: ChemComp-DMS: ChemComp-PG4: ChemComp-SO4: ChemComp-EDO: ChemComp-HOH: ChemComp-FNV: |
Source |
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Keywords | Protein Binding / Transcription / inhibitor |