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Structure paper

TitleCrystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Journal, issue, pagesNat. Chem. Biol., Vol. 15, Page 8-10, Year 2019
Publish dateAug 29, 2018 (structure data deposition date)
AuthorsMorimoto, K. / Suno, R. / Hotta, Y. / Yamashita, K. / Hirata, K. / Yamamoto, M. / Narumiya, S. / Iwata, S. / Kobayashi, T.
External linksNat. Chem. Biol. / PubMed:30510192
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-6ak3:
Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-P2E:
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid / medication*YM

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / GPCR / lipid / signaling protein / prostanoid receptor

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