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-Structure paper
Title | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 3037-3058, Year 2018 |
Publish date | Aug 21, 2017 (structure data deposition date) |
Authors | Zhang, M. / Zhang, Y. / Song, M. / Xue, X. / Wang, J. / Wang, C. / Zhang, C. / Li, C. / Xiang, Q. / Zou, L. ...Zhang, M. / Zhang, Y. / Song, M. / Xue, X. / Wang, J. / Wang, C. / Zhang, C. / Li, C. / Xiang, Q. / Zou, L. / Wu, X. / Wu, C. / Dong, B. / Xue, W. / Zhou, Y. / Chen, H. / Wu, D. / Ding, K. / Xu, Y. |
External links | J. Med. Chem. / PubMed:29566488 |
Methods | X-ray diffraction |
Resolution | 1.42 - 2 Å |
Structure data | PDB-5y8c: PDB-5y8w: PDB-5y8y: PDB-5y8z: PDB-5y93: PDB-5y94: |
Chemicals | ChemComp-NO3: ChemComp-8P9: ChemComp-EDO: ChemComp-GOL: ChemComp-HOH: ChemComp-8PU: ChemComp-NA: ChemComp-8PX: ChemComp-8Q3: ChemComp-8Q9: ChemComp-8QC: |
Source |
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Keywords | TRANSCRIPTION / BRD4(1) / Bromodomain |