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Title | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. |
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Journal, issue, pages | Cancer Discov, Vol. 8, Page 458-477, Year 2018 |
Publish date | Jul 28, 2017 (structure data deposition date) |
Authors | Ozer, H.G. / El-Gamal, D. / Powell, B. / Hing, Z.A. / Blachly, J.S. / Harrington, B. / Mitchell, S. / Grieselhuber, N.R. / Williams, K. / Lai, T.H. ...Ozer, H.G. / El-Gamal, D. / Powell, B. / Hing, Z.A. / Blachly, J.S. / Harrington, B. / Mitchell, S. / Grieselhuber, N.R. / Williams, K. / Lai, T.H. / Alinari, L. / Baiocchi, R.A. / Brinton, L. / Baskin, E. / Cannon, M. / Beaver, L. / Goettl, V.M. / Lucas, D.M. / Woyach, J.A. / Sampath, D. / Lehman, A.M. / Yu, L. / Zhang, J. / Ma, Y. / Zhang, Y. / Spevak, W. / Shi, S. / Severson, P. / Shellooe, R. / Carias, H. / Tsang, G. / Dong, K. / Ewing, T. / Marimuthu, A. / Tantoy, C. / Walters, J. / Sanftner, L. / Rezaei, H. / Nespi, M. / Matusow, B. / Habets, G. / Ibrahim, P. / Zhang, C. / Mathe, E.A. / Bollag, G. / Byrd, J.C. / Lapalombella, R. |
External links | Cancer Discov / PubMed:29386193 |
Methods | X-ray diffraction |
Resolution | 1.19 - 1.401 Å |
Structure data | PDB-5wma: PDB-5wmd: PDB-5wmg: |
Chemicals | ChemComp-EDO: ChemComp-6JC: ChemComp-HOH: ChemComp-6JE: ChemComp-6JF: |
Source |
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Keywords | TRANSCRIPTION/TRANSCRIPTION INHIBITOR / bromodomain / BRD4 / transcription / PLX5981 / transcription-transcription inhibitor complex / OTX-015 / PLX51107 |