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-Structure paper
Title | Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease. |
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Journal, issue, pages | Eur J Med Chem, Vol. 127, Page 41-61, Year 2016 |
Publish date | Sep 27, 2016 (structure data deposition date) |
Authors | Damalanka, V.C. / Kim, Y. / Galasiti Kankanamalage, A.C. / Lushington, G.H. / Mehzabeen, N. / Battaile, K.P. / Lovell, S. / Chang, K.O. / Groutas, W.C. |
External links | Eur J Med Chem / PubMed:28038326 |
Methods | X-ray diffraction |
Resolution | 1.4 - 1.75 Å |
Structure data | PDB-5tg1: PDB-5tg2: |
Chemicals | ChemComp-CL: ChemComp-V56: ChemComp-HOH: ChemComp-V69: |
Source |
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Keywords | PROTEASE/PROTEASE INHIBITOR / PROTEASE / NOROVIRUS / NORWALK VIRUS / ANTIVIRAL INHIBITORS / MACROCYCLIC INHIBITOR / PROTEASE-PROTEASE INHIBITOR complex / HYDROLASE-HYDROLASE inhibitor complex |