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TitleDesign of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 668-680, Year 2017
Publish dateAug 30, 2016 (structure data deposition date)
AuthorsIgoe, N. / Bayle, E.D. / Fedorov, O. / Tallant, C. / Savitsky, P. / Rogers, C. / Owen, D.R. / Deb, G. / Somervaille, T.C. / Andrews, D.M. ...Igoe, N. / Bayle, E.D. / Fedorov, O. / Tallant, C. / Savitsky, P. / Rogers, C. / Owen, D.R. / Deb, G. / Somervaille, T.C. / Andrews, D.M. / Jones, N. / Cheasty, A. / Ryder, H. / Brennan, P.E. / Muller, S. / Knapp, S. / Fish, P.V.
External linksJ. Med. Chem. / PubMed:28068087
MethodsX-ray diffraction
Resolution1.5 - 1.65 Å
Structure data

PDB-5t4u:
Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-5t4v:
Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-NO3:
NITRATE ION

ChemComp-12Q:
1-METHYLQUINOLIN-2(1H)-ONE

ChemComp-HOH:
WATER

ChemComp-N48:
4-cyano-N-(7-methoxy-1,4-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzene-1-sulfonamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Structural Genomics / PSI-2 / Protein Structure Initiative / Structural Genomics Consortium / SGC

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