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Title | Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. |
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Journal, issue, pages | Eur J Med Chem, Vol. 152, Page 160-174, Year 2018 |
Publish date | Aug 23, 2017 (structure data deposition date) |
Authors | Crespo, I. / Gimenez-Dejoz, J. / Porte, S. / Cousido-Siah, A. / Mitschler, A. / Podjarny, A. / Pratsinis, H. / Kletsas, D. / Pares, X. / Ruiz, F.X. ...Crespo, I. / Gimenez-Dejoz, J. / Porte, S. / Cousido-Siah, A. / Mitschler, A. / Podjarny, A. / Pratsinis, H. / Kletsas, D. / Pares, X. / Ruiz, F.X. / Metwally, K. / Farres, J. |
External links | Eur J Med Chem / PubMed:29705708 |
Methods | X-ray diffraction |
Resolution | 0.94 - 0.96 Å |
Structure data | PDB-5ou0: PDB-5ouj: PDB-5ouk: |
Chemicals | ChemComp-NAP: ChemComp-AV5: ChemComp-HOH: ChemComp-AW8: ChemComp-AVT: |
Source |
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Keywords | OXIDOREDUCTASE / alpha-beta TIM barrel / cytosol / aldo-keto reductase / pyrimido[4 / 5-c]quinolone-2-acetic acid scaffold |