+Search query
-Structure paper
Title | Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. |
---|---|
Journal, issue, pages | Eur J Med Chem, Vol. 152, Page 160-174, Year 2018 |
Publish date | Aug 23, 2017 (structure data deposition date) |
![]() | Crespo, I. / Gimenez-Dejoz, J. / Porte, S. / Cousido-Siah, A. / Mitschler, A. / Podjarny, A. / Pratsinis, H. / Kletsas, D. / Pares, X. / Ruiz, F.X. ...Crespo, I. / Gimenez-Dejoz, J. / Porte, S. / Cousido-Siah, A. / Mitschler, A. / Podjarny, A. / Pratsinis, H. / Kletsas, D. / Pares, X. / Ruiz, F.X. / Metwally, K. / Farres, J. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 0.94 - 0.96 Å |
Structure data | ![]() PDB-5ou0: ![]() PDB-5ouj: ![]() PDB-5ouk: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-AV5: ![]() ChemComp-HOH: ![]() ChemComp-AW8: ![]() ChemComp-AVT: |
Source |
|
![]() | OXIDOREDUCTASE / alpha-beta TIM barrel / cytosol / aldo-keto reductase / pyrimido[4 / 5-c]quinolone-2-acetic acid scaffold |