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-Structure paper
Title | Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201. |
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Journal, issue, pages | Cancer Res., Vol. 78, Page 6257-6267, Year 2018 |
Publish date | Jun 29, 2017 (structure data deposition date) |
Authors | Jeay, S. / Ferretti, S. / Holzer, P. / Fuchs, J. / Chapeau, E.A. / Wartmann, M. / Sterker, D. / Romanet, V. / Murakami, M. / Kerr, G. ...Jeay, S. / Ferretti, S. / Holzer, P. / Fuchs, J. / Chapeau, E.A. / Wartmann, M. / Sterker, D. / Romanet, V. / Murakami, M. / Kerr, G. / Durand, E.Y. / Gaulis, S. / Cortes-Cros, M. / Ruetz, S. / Stachyra, T.M. / Kallen, J. / Furet, P. / Wurthner, J. / Guerreiro, N. / Halilovic, E. / Jullion, A. / Kauffmann, A. / Kuriakose, E. / Wiesmann, M. / Jensen, M.R. / Hofmann, F. / Sellers, W.R. |
External links | Cancer Res. / PubMed:30135191 |
Methods | X-ray diffraction |
Resolution | 1.56 Å |
Structure data | PDB-5oc8: |
Chemicals | ChemComp-9QW: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | LIGASE / PPI WITH P53 / INHIBITOR COMPLEX / CELL CYCLE |