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Structure paper

TitleDevelopment of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
Journal, issue, pagesACS Chem. Biol., Vol. 12, Page 825-832, Year 2017
Publish dateJan 25, 2017 (structure data deposition date)
AuthorsBatson, J. / Toop, H.D. / Redondo, C. / Babaei-Jadidi, R. / Chaikuad, A. / Wearmouth, S.F. / Gibbons, B. / Allen, C. / Tallant, C. / Zhang, J. ...Batson, J. / Toop, H.D. / Redondo, C. / Babaei-Jadidi, R. / Chaikuad, A. / Wearmouth, S.F. / Gibbons, B. / Allen, C. / Tallant, C. / Zhang, J. / Du, C. / Hancox, J.C. / Hawtrey, T. / Da Rocha, J. / Griffith, R. / Knapp, S. / Bates, D.O. / Morris, J.C.
External linksACS Chem. Biol. / PubMed:28135068
MethodsX-ray diffraction
Resolution1.7 - 2.9 Å
Structure data

PDB-5mxx:
Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-5my8:
Crystal structure of SRPK1 in complex with SPHINX31
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5myv:
Crystal structure of SRPK2 in complex with compound 1
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-W4A:
5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CA:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-RXZ:
SPHINX31

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsSPLICING / phosphorylation / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE / splicing kinase / inhibitor / kinase

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