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-Structure paper
Title | Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2. |
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Journal, issue, pages | J. Mol. Biol., Vol. 429, Page 208-219, Year 2017 |
Publish date | Jun 1, 2016 (structure data deposition date) |
Authors | Popovic, B. / Breed, J. / Rees, D.G. / Gardener, M.J. / Vinall, L.M. / Kemp, B. / Spooner, J. / Keen, J. / Minter, R. / Uddin, F. ...Popovic, B. / Breed, J. / Rees, D.G. / Gardener, M.J. / Vinall, L.M. / Kemp, B. / Spooner, J. / Keen, J. / Minter, R. / Uddin, F. / Colice, G. / Wilkinson, T. / Vaughan, T. / May, R.D. |
External links | J. Mol. Biol. / PubMed:27956146 |
Methods | X-ray diffraction |
Resolution | 1.99 Å |
Structure data | PDB-5l6y: |
Chemicals | ChemComp-FMT: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / IL13 antibody tralokinumab asthma / IL13 |