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| Title | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 59, Page 4711-4723, Year 2016 |
| Publish date | Feb 29, 2016 (structure data deposition date) |
 Authors | Toure, B.B. / Giraldes, J. / Smith, T. / Sprague, E.R. / Wang, Y. / Mathieu, S. / Chen, Z. / Mishina, Y. / Feng, Y. / Yan-Neale, Y. ...Toure, B.B. / Giraldes, J. / Smith, T. / Sprague, E.R. / Wang, Y. / Mathieu, S. / Chen, Z. / Mishina, Y. / Feng, Y. / Yan-Neale, Y. / Shakya, S. / Chen, D. / Meyer, M. / Puleo, D. / Brazell, J.T. / Straub, C. / Sage, D. / Wright, K. / Yuan, Y. / Chen, X. / Duca, J. / Kim, S. / Tian, L. / Martin, E. / Hurov, K. / Shao, W. |
 External links | J. Med. Chem. / PubMed:27187609 |
| Methods | X-ray diffraction |
| Resolution | 1.79 - 2.14 Å |
| Structure data |  PDB-5ih8:  PDB-5ih9:  PDB-5iha:  PDB-5ihc: |
| Chemicals |  ChemComp-6BJ:  ChemComp-HOH:  ChemComp-6BF:  ChemComp-6BE:  ChemComp-6BB: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase UBA domain inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)