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-Structure paper
Title | Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. |
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Journal, issue, pages | Sci Adv, Vol. 2, Page e1600760-e1600760, Year 2016 |
Publish date | Feb 28, 2016 (structure data deposition date) |
![]() | Picaud, S. / Leonards, K. / Lambert, J.P. / Dovey, O. / Wells, C. / Fedorov, O. / Monteiro, O. / Fujisawa, T. / Wang, C.Y. / Lingard, H. ...Picaud, S. / Leonards, K. / Lambert, J.P. / Dovey, O. / Wells, C. / Fedorov, O. / Monteiro, O. / Fujisawa, T. / Wang, C.Y. / Lingard, H. / Tallant, C. / Nikbin, N. / Guetzoyan, L. / Ingham, R. / Ley, S.V. / Brennan, P. / Muller, S. / Samsonova, A. / Gingras, A.C. / Schwaller, J. / Vassiliou, G. / Knapp, S. / Filippakopoulos, P. |
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Methods | X-ray diffraction |
Resolution | 1.6 - 2.1 Å |
Structure data | ![]() PDB-5igk: ![]() PDB-5igl: ![]() PDB-5igm: |
Chemicals | ![]() ChemComp-EDO: ![]() ChemComp-BMF: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / post translational modifications / BET family / Structural Genomics / Structural Genomics Consortium / SGC / TAF1/TAFII250 / chromatin remodeling |