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-Structure paper
Title | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 498-501, Year 2016 |
Publish date | Feb 18, 2016 (structure data deposition date) |
Authors | Wu, W.L. / Hao, J. / Domalski, M. / Burnett, D.A. / Pissarnitski, D. / Zhao, Z. / Stamford, A. / Scapin, G. / Gao, Y.D. / Soriano, A. ...Wu, W.L. / Hao, J. / Domalski, M. / Burnett, D.A. / Pissarnitski, D. / Zhao, Z. / Stamford, A. / Scapin, G. / Gao, Y.D. / Soriano, A. / Kelly, T.M. / Yao, Z. / Powles, M.A. / Chen, S. / Mei, H. / Hwa, J. |
External links | Acs Med. Chem. Lett. / PubMed:27190600 |
Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | PDB-5i7u: |
Chemicals | ChemComp-NAG: ChemComp-6AJ: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Structure-based drug design / diabetes / DPP4 inhibitors / hydrolase / Hydrolase-Hydrolase Inhibitor complex |